1, 4, 5, 6-tetrahydropyrazolo-¬3, 4-c|-pyridin-7-ones as...

Details 1, 4, 5, 6-tetrahydropyrazolo-¬3, 4-c|-pyridin-7-ones as... 1, 4, 5, 6-tetrahydropyrazolo-¬3, 4-c|-pyridin-7-ones as...

C - Chemistry, Metallurgy

07

D

C07D 471/04 (2006.01) A61K 31/437 (2006.01) A61K 31/44 (2006.01) A61P 7/02 (2006.01) A61P 9/00 (2006.01)

Patent

CA 2444571

The present application describes 1, 4, 5, 6-tetrahydropyrazolo-[3, 4-c]- pyridin-7-ones of the following formula or pharmaceutically acceptable salt forms thereof: wherein ring Rb is 3-amido or 4-methoxy, Ra can be cyano, trifluoromethyl, or amido, and R can be a substituted phenyl, a substituted imidazolyl, or a substituted pyridine. Compounds of the present invention are useful as inhibitors of trypsin-like serine proteases, specifically factor Xa.

L'invention concerne des 1, 4, 5, 6-tétrahydropyrazolo-[3, 4-c]-pyridine-7-ones de formule suivante ou leur sels pharmaceutiquement acceptables, dans laquelle le cycle R?b¿ représente un 3-amido ou 4-méthoxy, R?a¿ peut être un cyano, trifluorométhyle, ou amido et R peut être un phényle substituté, un imidazolyle substitué ou une pyridine substituée. Les composés de cette invention sont utiles comme inhibiteurs de sérine protéases de type trypsine, plus particulièrement du facteur XA.

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