1, 4, 5-substituted 1, 2-dihydro-pyrazol-3-one and...

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 401/14 (2006.01) A61K 31/4439 (2006.01) A61K 31/4545 (2006.01) C07D 401/04 (2006.01)

Patent

CA 2497007

The present invention relates to compounds having the general formula (I) or a pharmaceutically acceptable salt thereof. Also included is a method of prophylaxis or treatment of inflammation, rheumatoid arthritis, Pagets disease, osteoporosis, multiple myeloma, uveititis, acute or chronic myelogenous leukemia, pancreatic .beta. cell destruction, osteoarthritis, rheumatoid spondylitis, gouty arthritis, inflammatory bowel disease, adult respiratory distress syndrome (ARDS), psoriasis,Crohn's disease, allergic rhinitis, ulcerative colitis, anaphylaxis, contact dermatitis, asthma, muscle degeneration, cachexia, Reiter's syndrome, type I diabetes, type II diabetes, bone resorption diseases, graft vs. host reaction, Alzheimer's disease, stroke, myocardial infarction, ischemia reperfusion injury, atherosclerosis, brain trauma, multiple sclerosis, cerebral malaria, sepsis, septic shock, toxic shock syndrome, fever, myalgias due to HIV-1, HIV-2, HIV-3, cytomegalovirus (CMV), influenza, adenovirus, the herpes viruses or herpes zoster infection in a mammal comprising administering an effective amount a compound as described above.

La présente invention porte sur des composés ayant la formule générale (I) ou sur un sel de ce composé acceptable d'un point de vue pharmaceutique. L'invention porte également sur un procédé visant à prévenir ou traiter les inflammations, l'arthrite rhumatoïde, la maladie de Paget, l'ostéoporose, le myélome multiple, l'uvéite, la leucémie myéloïde aiguë ou chronique, la destruction des lymphocytes B pancréatiques, l'ostéoarthrite, la spondylite rhumatoïde, l'arthrite goutteuse, la maladie intestinale inflammatoire, la pneumopathie atypique chez l'adulte (SRAS), le psoriasis, la maladie de Crohn, la rhinite allergique, la colite ulcérative, l'anaphylaxie, la dermite de contact, l'asthme, la dégénérescence musculaire, la cachexie, le syndrome Reiter, le diabète de type I, le diabète de type II, les maladies de la résorption osseuse, le rejet de greffe, la maladie d'Alzheimer, l'accident cérébro-vasculaire, l'infarctus du myocarde, les lésions de reperfusion ischémiques, l'athérosclérose, le traumatisme cérébral, la sclérose en plaques, l'accès pernicieux à forme cérébrale, la sepsis, le choc septique, le syndrome du choc toxique, la fièvre, les myalgies dues au VIH-1, VIH-2, VIH-3, le cytomégalovirus (CMV), la grippe, l'adénovirus, les virus de l'herpès ou zona chez un mammifère. Ce procédé consiste à administrer une quantité efficace du composé précité.

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