1-(4-acylaminophenyl)-7,8-methylenedioxy-5h-2,3-benzo-...

Details 1-(4-acylaminophenyl)-7,8-methylenedioxy-5h-2,3-benzo-... 1-(4-acylaminophenyl)-7,8-methylenedioxy-5h-2,3-benzo-...

C - Chemistry, Metallurgy

07

D

C07D 491/056 (2006.01) A61K 31/55 (2006.01) C07D 491/04 (2006.01)

Patent

CA 2098291

2098291 9211262 PCTABS00014 The invention relates to novel compounds of general formula (I), wherein R stands for hydrogen or a C1-4 alkyl group optionally substituted by a carboxyl or C2-5 alkoxycarbonyl group; and R1 means an aliphatic C1-6 acyl, benzoyl or phenylacetyl group, and the stereoisomers as well as acid-addition salts of these compounds. The invention also relates to pharmaceutical compositions containing the above compounds as well as to a process for the preparation of the novel compounds of general formula (I). The compounds of the invention possess central nervous system effects, more particularly antidepressive and antiparkinsonian action. They are non-mutagenic in the Ames test. Thus, they can be useful for the treatment of depressive illnesses and parkinsonism.

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