1-(4-aminophenyl)-4-methyl-7,8-methylenedioxy-3,4-...

Details 1-(4-aminophenyl)-4-methyl-7,8-methylenedioxy-3,4-... 1-(4-aminophenyl)-4-methyl-7,8-methylenedioxy-3,4-...

C - Chemistry, Metallurgy

07

D

167/210, 260/239

C07D 491/056 (2006.01) A61K 31/55 (2006.01) C07D 491/04 (2006.01)

Patent

CA 1284322

ABSTRACT The invention relates to new 1-/4-aminophenyl/-4- -methyl-7,8-methylenedioxy-3,4-dihydro-5H-2,3-benzodiazepine of formula /I/, optically active isomers and acid addition salts thereof as well as to pharmaceutical compositions containing these compounds. Image /I/ The new compounds of formula /I/ can be prepared by reducing l-/4-aminophenyl/-4-methyl-7,8-methylenedioxy- -5H-2,3-benzodiazepine of formula /II/ with an inorganic or organic-inorganic and/or complex metal hydride and, if desired, separating the optically active forms of the compound of formula /I/ thus-obtained and, if desired, converting the base or bases into acid addition salts or converting the salts into the free base/s/. /II/ Image The new compound of formula /I/ possesses significant central nervous effects and can advantageously be used in the therapy.

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