1,4-benzodiazepin-2-ones useful as hiv reverse transcriptase...

Details 1,4-benzodiazepin-2-ones useful as hiv reverse transcriptase... 1,4-benzodiazepin-2-ones useful as hiv reverse transcriptase...

C - Chemistry, Metallurgy

07

D

C07D 243/14 (2006.01) A61K 31/5513 (2006.01) A61P 31/18 (2006.01) C07D 243/24 (2006.01) C07D 401/06 (2006.01) C07D 405/06 (2006.01) C07D 409/06 (2006.01) C07D 417/06 (2006.01)

Patent

CA 2370141

The present invention relates to 1,4-benzodiazepin-2-ones of Formula (I) or stereoisomeric forms, stereoisomeric mixtures, or pharmaceutically acceptable salt forms thereof, which are useful as inhibitors of HIV reverse transcriptase, and to pharmaceutical compositions and diagnostic kits comprising the same, and methods of using the same for treating viral infection or as an assay standard or reagent.

La présente invention concerne des 1,4-benzodiazépin-2-ones représentées par la formule générale (I), certaines de leurs formes stéréoisomères, certains de leurs mélanges stéréoisomères, ou certains de leurs sels pharmaceutiquement admis, et convenant comme inhibiteurs de transcriptase inverse du VIH. L'invention concerne également des compositions pharmaceutiques et des nécessaires de diagnostic comprenant les objets de l'invention. L'invention concerne enfin des procédés permettant d'utiliser ces mêmes objets pour le traitement d'une infection virale, ou comme standard ou réactif d'essai.

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