1,4-benzothiazepine derivatives

Details 1,4-benzothiazepine derivatives 1,4-benzothiazepine derivatives

C - Chemistry, Metallurgy

07

D

C07D 417/06 (2006.01) A61K 31/55 (2006.01) C07D 417/14 (2006.01)

Patent

CA 2098495

[Object] An object of the invention is to provide compounds having a myocardial KD (Kinetic cell death)-inhibiting effect without being accompanied by a cardiodepressant effect. [Construction] A 1,4-benzothiazepine derivative represented by the following Formula [I]: Image wherein each of substituent groups is defined as follows: R represents H or a C1 - C3 lower alkoxy group; X represents O or H2; n represents 1 or 2; R1 represents H, a substituted phenyl group wherein the substituent group is OH or a C1-C3 lower alkoxy group, Image a C1 - C3 lower alkoxy group, Image wherein R2 represents a C1 - C3 aryl group, and ph represents a phenyl group, or a pharmaceutically acceptable salt thereof. 34

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