1,4-benzoxazine-2-acetic acid compound, process for...

Details 1,4-benzoxazine-2-acetic acid compound, process for... 1,4-benzoxazine-2-acetic acid compound, process for...

C - Chemistry, Metallurgy

07

D

C07D 417/06 (2006.01) A61K 31/535 (2006.01)

Patent

CA 2180340

A 1,4-benzoxazine-2-acetic acid compound of the formula (I) Image (I) wherein each symbol is as defined in the specification, a pharmaceutically acceptable salt thereof, a method for production thereof, and a pharmaceutical composition, an aldose reductase inhibitor and an agent for the prevention and/or treatment of the complications of diabetes, which contain the same. The compound (I) of the present invention and pharmaceutically acceptable salts thereof have aldose reductase inhibitory action and are superior in safety. Accordingly, they are useful as an agent for the prevention and/or treatment of the complications of diabetes such as faulty union of corneal injury, cataract, neurosis, retinopAthy and nephropathy, in particular, cataract and neurosis.

Composé d'acide 1,4-benzoxazine-2-acétique représenté par la formule générale (I) ou un sel médicinalement acceptable de celui-ci, son procédé de production et composition médicinale le contenant, comprenant un inhibiteur d'aldose réductase ainsi qu'un médicament de prévention ou de traitement de complications du diabète. La définition de chaque symbole figure dans la description. Le composé (I) ainsi que le sel présentent une activité d'inhibiteur d'aldose réductase ainsi qu'une excellente sécurité, par conséquent ils sont utiles en tant que médicament de prévention ou de traitement de complications du diabète, telles que la mauvaise conjonction de lésions de la cornée, de la cataracte, de la névrose, la rétinopathie et de la néphropathie, et en particulier de la cataracte et de la névrose.

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