1,4-benzoxazine derivatives

C - Chemistry – Metallurgy – 07 – D

Patent

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C07D 265/34 (2006.01) A61K 31/535 (2006.01) C07D 265/36 (2006.01) C07D 413/12 (2006.01)

Patent

CA 2110520

ABSTRACT A 1,4-benzoxazine derivative represented by the following formula (1): Image (1) wherein R1 represents an unsubstituted or halogen- substituted lower alkyl, unsubstituted or halogen- substituted lower alkylsulfonyl, nitro or cyano group, R2 and R3 may be the same or different and individually represent a hydrogen atom or a lower alkyl group or are fused together with the adjacent carbon atom into a 3- to 6-membered carbon ring, R4 represents a hydrogen atom or an unsubstituted or substituted lower alkyl or acyl group, R5 represents a hydrogen atom or a un- substituted or substituted lower alkyl, lower alkenyl, lower alkoxyl, aryl, aryloxyl or heterocyclic ring group, and Y represents an oxygen or sulfur atom, with the proviso that R1 is other than a nitro or cyano group when R2 and R3 are individually a methyl group, R4 is a hydrogen atom, R5 is a 3-chloropropyl group and Y is an oxygen atom; or a salt thereof. These compounds are useful as medicinal drugs, especially as preventives or therapeutics for circulatory diseases or bronchial diseases.

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