1,4-bis-(amino-hydroxyalkylamino)-anthraquinones for...

Details 1,4-bis-(amino-hydroxyalkylamino)-anthraquinones for... 1,4-bis-(amino-hydroxyalkylamino)-anthraquinones for...

C - Chemistry, Metallurgy

07

C

C07C 225/36 (2006.01) A61K 31/135 (2006.01) A61K 31/165 (2006.01) A61K 31/195 (2006.01) A61K 31/44 (2006.01) C07C 225/34 (2006.01) C07C 229/74 (2006.01) C07C 237/48 (2006.01) C07D 213/50 (2006.01)

Patent

CA 2072884

2072884 9207558 PCTABS00013 The present invention provides novel substituted anthraquinones having formula (I), wherein R1 and R2 are independently H, alkyl, aryl, or arylalkyl; m and n are independently 1, 2, or 3; X is H, OH, NR3R4, Cl, Br, I, F, alkyl, aryl alkoxy, aroxy, COOR5, or CONR6R7; R3, R4, R5, R6, and R7 are independently H, lower alkyl or aryl useful for inhibiting protein kinase C and treating conditions related to, or affected by inhibition of protein kinase C, particularly cancer tumors, inflammatory disease, reperfusion injury, and cardiac dysfunctions related to reperfusion injury.

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