1,4 -di substituted 3-cyano-pyridone derivatives and their...

Details 1,4 -di substituted 3-cyano-pyridone derivatives and their... 1,4 -di substituted 3-cyano-pyridone derivatives and their...

C - Chemistry, Metallurgy

07

D

C07D 213/85 (2006.01) A61K 31/4412 (2006.01) A61K 31/4418 (2006.01) A61K 31/443 (2006.01) A61K 31/4436 (2006.01) A61K 31/4439 (2006.01) A61K 31/444 (2006.01) A61P 25/22 (2006.01) C07D 401/04 (2006.01) C07D 401/06 (2006.01) C07D 401/10 (2006.01) C07D 401/12 (2006.01) C07D 401/14 (2006.01) C07D 405/04 (2006.01) C07D 409/04 (2006.01)

Patent

CA 2640534

The present invention relates to novel compounds, in particular novel pyridinone derivatives according to Formula (I) wherein all radicals are defined in the application and claims. The compounds according to the invention are positive allosteric modulators of metabotropic receptors - sub- type 2 ("mGluR2") which are useful for the treatment or prevention of neurological and psychiatric disorders associated with glutamate dysfunction and diseases in which the mGluR2 subtype of metabotropic receptors is involved. In particular, such diseases are central nervous system disorders selected from the group of anxiety, schizophrenia, migraine, depression, and epilepsy. The invention is also directed to pharmaceutical composit ions and processes to prepare such compounds and compositions, as well as to the use of such compounds for the prevention and treatment of such diseases in which mGluR2 is involved.

La présente invention concerne de nouveaux composés, en particulier de nouveaux dérivés de pyridinone de Formule (I) où tous les radicaux sont définis comme dans la demande et les revendications. Les composés selon l'invention sont des modulateurs allostériques positifs des récepteurs métabotropiques de sous-type 2 (<= mGluR2 >=) qui peuvent être employés dans le traitement prophylactiqueou thérapeutique de troubles neurologiques et psychiatriques associés à un dysfonctionnement lié au glutamate et de maladies impliquant le sous-type mGluR2 des récepteurs métabotropiques. En particulier, de telles maladies incluent les troubles du système nerveux central sélectionnés au sein du groupe constitué par l'anxiété, la schizophrénie, la migraine, la dépression et l'épilepsie. La présente invention concerne également des compositions pharmaceutiques et des procédés d'élaboration de tels composés et compositions, ainsi que l'emploi de tels composés dans le traitement prophylactique et thérapeutique de maladies impliquant mGluR2.

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