1,4 diamino bicyclic retigabine analogues as potassium...

Details 1,4 diamino bicyclic retigabine analogues as potassium... 1,4 diamino bicyclic retigabine analogues as potassium...

C - Chemistry, Metallurgy

07

C

C07C 233/41 (2006.01) A61K 31/165 (2006.01) C07C 271/30 (2006.01)

Patent

CA 2670966

This invention is directed to compounds of formula (I), where G is -O-, -S-, -C(g1)(g2)-, or -NH-, and n = 1, 2, or 3. Such compounds modulate potassium channels. The compounds are useful for the treatment and prevention of diseases and disorders which are affected by modulation of potassium ion channels. One such condition is seizure disorders.

L'invention concerne les composés représentés par la formule (I), où G est -O-, -S-, -C(g1)(g2)- ou -NH-, et n =1, 2 ou 3. De tels composés modulent les canaux potassiques. Les composés sont utiles pour le traitement de maladies et de troubles qui sont induits par une modulation des canaux des ions potassium. Une telle affection concerne les troubles convulsifs.

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