(1,4-diaza-bicyclo[3.2.2]non-6-en-4-yl)-heterocyclyl-methano...

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 453/00 (2006.01) A61K 31/40 (2006.01) A61K 31/4045 (2006.01) A61K 31/43 (2006.01) A61K 31/439 (2006.01) C07D 307/78 (2006.01)

Patent

CA 2703163

The present invention relates generally to the field of ligands for nicotinic acetylcholine receptors (nACh receptors), activation of nACh receptors, and the treatment of disease conditions associated with defective or malfunctioning nicotinic acetylcholine receptors, especially of the brain. Further, this invention relates to novel compounds, which act as ligands for the a7 nACh receptor subtype, methods of preparing such compounds, compositions containing such compounds, and methods of use thereof. The novel compounds include compounds of formula I: (I) wherein X, R1, and R2 are as herein defined.

La présente invention concerne de manière générale le domaine des ligands des récepteurs nicotiniques d'acétylcholine (récepteurs nACh), l'activation des récepteurs nACh, et le traitement de conditions pathologiques associées à des récepteurs nicotiniques d'acétylcholine défectueux ou fonctionnant mal, en particulier dans le cerveau. En outre, cette invention concerne de nouveaux composés qui agissent comme des ligands pour le sous-type de récepteur nACh a7, des procédés de préparation de ces composés, des compositions contenant ces composés, et des procédés pour les utiliser. Les nouveaux composés comprennent des composés de formule I : (I) dans laquelle X, R1, et R2 sont tels que définis ici.

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