1,4-diazabicyclo [2.2.2] oct-2-ylmethyl derivatives, their...

Details 1,4-diazabicyclo [2.2.2] oct-2-ylmethyl derivatives, their... 1,4-diazabicyclo [2.2.2] oct-2-ylmethyl derivatives, their...

C - Chemistry, Metallurgy

07

D

C07D 487/08 (2006.01) A61K 31/495 (2006.01)

Patent

CA 2271072

The invention concerns compounds of general formula (I) in which R¿1? represents a methyl group, X¿1? represents a hydrogen atom, or OR¿1? and X¿1? together form a group of formula -O(CH¿2?)¿2?-, -O(CH¿2?)¿3?-, -O(CH¿2?)¿2?O-, or -O(CH¿2?)¿3?O-, X¿2? represents a hydrogen atom or an amino group, and X¿3? represents a halogen atom. The compounds are ligands of serotoninergic receptors of the 5-HT¿3? and/or 5-HT¿4? types, and act as 5-HT¿4? agonists and/or 5-HT¿3? antagonists.

Composés répondant à la formule générale (I) dans laquelle R1 représente un groupe méthyle, X1 représente un atome d'hydrogène, ou bien OR1 et X1 forment ensemble un groupe de formule -O(CH2)2-, -O(CH2)3-, -O(CH2)2O- ou -O(CH2)3O, X2 représente un atome d'hydrogène ou un groupe amino, et X3 représente un atome d'halogène. Les composés de l'invention sont des ligands des récepteurs sérotoninergiques de types 5-HT3 et/ou 5-HT4, et qu'ils agissent comme des agonistes 5-HT4 et/ou comme des antagonistes 5-HT3.

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