1,4-diazacycloheptane derivatives

Details 1,4-diazacycloheptane derivatives 1,4-diazacycloheptane derivatives

C - Chemistry, Metallurgy

07

D

C07D 243/08 (2006.01) A61K 31/55 (2006.01)

Patent

CA 2312070

Compounds of formula (I): wherein R is hydrogen, C1-10alkyl, C3-8cycloalkyl, C3-8cycloalkylC1-6alkyl, phenylC1-6alkyl or phenyl; R1 is C1-6alkyl, C2- 6alkenyl, C1-6alkoxy, halo, hydroxy, C1-6alkanoyl, haloC1-6alkyl, cyano or nitro; m is 0, 1 or 2; R2 is C1-6alkyl; n is 0, 1 or 2; are empomil inhibitors and are useful in the treatment of neurological disorders such as stroke, head trauma, transient cerebral ischemic attack, and chronic neurodegenerative disorders such as Alzheimer's disease, Parkinson's disease, diabetic neuropathy, amyotrophic lateral sclerosis, multiple sclerosis, vascular dementia and AIDS-related dementia.

L'invention concerne les composés représentés par la formule (I), dans laquelle R est l'hydrogène, alkyle C¿1-10?, cycloalkyle C¿3-8?, cycloalkyl C¿3-8?-alkyle C¿1-6?, phényl-alkyle C¿1-6? ou phényle; R?1¿ est alkyle C¿1-6?, alcényle C¿2-6?, alcoxy C¿1-6?, halo, hydroxy, alcanoyle C¿1-6?, halo-alkyle C¿1-6?, cyano ou nitro; m est 0, 1 ou 2; R?2¿ est alkyle C¿1-6?; n est 0, 1 ou 2. Ces composants sont des inhibiteurs d'empomil et sont utiles dans le traitement de troubles neurologiques tels que l'ictus, les traumatismes crâniens, les accidents ischémiques transitoires, et les troubles neurodégénératifs chroniques tels que la maladie d'Alzheimer, la maladie de Parkinson, la neuropathie diabétique, la sclérose latérale amyotrophique, la sclérose en plaques, les démences d'origine vasculaire et les démences associées au SIDA.

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