C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 409/04 (2006.01) A61K 31/55 (2006.01)
Patent
CA 2313226
Compounds of formula (I), wherein R is hydrogen, C1-10alkyl, C3-8cycloalkyl, C3-8cycloalkylC1-6alkyl, phenylC1-6alkyl or phenyl; R1 is C1-6alkyl, C2- 6alkenyl, C1-6alkoxy, halo, hydroxy, C1-6alkanoyl, haloC1-6alkyl, cyano or nitro; m is 0, 1 or 2; R2 is C1-6alkyl; n is 0, 1 or 2; are empomil inhibitors and are useful in the treatment of neurological disorders such as stroke, head trauma, transient cerebral ischemic attack, and chronic neurodegenerative disorders such as Alzheimer's disease, Parkinson's disease, diabetic neuropathy, amyotrophic lateral sclerosis, multiple sclerosis, vascular dementia and AIDS-related dementia.
L'invention concerne des composés de formule (I): dans laquelle R représente hydrogène, un C¿1-10?alkyle, un C¿3-8?cycloalkyle, un C¿3-8?cycloalkylC¿1-6?alkyle, un phénylC¿1-6?alkyle ou un phényle; R?1¿ représente un C¿1-6?alkyle, un C¿2-6?alkényle, un C¿1-6?alcoxy, halo, hydroxy, un C¿1-6?alkanoyle, un haloC¿1-6?alkyle, cyano ou nitro; m est égal à 0, 1 ou 2; R?2¿ représente un C¿1-6?alkyle; n est égal à 0, 1 ou 2. Ces composés sont des inhibiteurs d'empomile et sont utilisés dans le traitement de troubles neurologiques tels que les accidents cérébrovasculaires, les traumatismes crâniens, les attaques ischémiques transitoires, et les troubles neurodégénératifs chroniques comme la maladie d'Alzheimer, la maladie de Parkinson, la neuropathie diabétique, la sclérose latérale amyotrophique, la sclérose en plaques, la démence vasculaire et la démence associée au sida.
Astrazeneca Uk Limited
Smart & Biggar
LandOfFree
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