1,4-dihydropyridine-3,5-dicarboxylic acid ester derivatives

Details 1,4-dihydropyridine-3,5-dicarboxylic acid ester derivatives 1,4-dihydropyridine-3,5-dicarboxylic acid ester derivatives

C - Chemistry, Metallurgy

07

D

260/278, 260/387

C07D 401/00 (2006.01) C07D 211/90 (2006.01) C07D 213/89 (2006.01) C07D 401/04 (2006.01) C07D 401/12 (2006.01) C07D 405/04 (2006.01) C07D 405/12 (2006.01) C07D 405/14 (2006.01) C07D 409/04 (2006.01) C07D 409/12 (2006.01) C07D 409/14 (2006.01) C07D 413/12 (2006.01) C07D 417/04 (2006.01) C07D 417/12 (2006.01) C07D 491/10 (2006.01)

Patent

CA 1192544

ABSTRACT OF THE DISCLOSURE 1,4-Dihydropyridine-3,5-dicarboxylic acid ester deri- vatives of the general formula: Image or acid addition salts thereof, wherein W is -CH= or -N=; Y is -CH=CH-, -O-, -S-, -CH=N(O)p- (p is zero or 1) or -N(R)- (R is hydrogen or lower alkyl); X1, X2 and X3 are the same or different, and are each hydrogen, halogen, nitro, trifluoromethyl, cyano or lower alkylthio; Z is aryl or 5- or 6-membered aromatic heterocyclic ring (which may have a substituent or two or three substituents which may be the same or different, and the substituent may be halogen, lower alkyl, lower alkoxy, lower alkanoylamino, cyano, nitro, lower alkylthio, trifluoromethyl, sulfamoyl, di-lower alkyl- sulfamoyl, amino or di-lower alkylamino); Image is 5- to 7- membered heterocyclic ring which may have nitrogen atom, oxygen atom, sulfur atom or unsaturated bond on the ring, and may be substituted by lower alkyl, lower alkoxycarbonyl, lower alkanoylamino, ethylenedioxy or -(CH2)m-OR4 (R4 is hydrogen, lower alkyl or lower alkanoyl and m is 0, 1 or 2); R1 and R2 are the same or different, and are each lower alkyl; R3 is lower alkyl, aralkyl, heteroaralkyl; and n is an integer 1 to 5. Such compounds are useful as antihyper- tensive agents and as therapeutic agents for cardiac and cerebral circulation disorders.

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