1,4-dihydropyridine and pyridine compounds as calcium...

C - Chemistry – Metallurgy – 07 – D

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C07D 211/90 (2006.01) A61K 31/4422 (2006.01) A61K 31/4436 (2006.01) A61K 31/4439 (2006.01) A61P 9/00 (2006.01) C07D 401/04 (2006.01)

Patent

CA 2473790

The present invention is directed in part towards methods of modulating the function of calcium channels with pyridine- or 1,4-dihydropyridine-based compounds. In addition, the invention describes methods of preventing and treating a cardiovascular disease or a neurological disorder in organisms with a compound identified by the invention. Furthermore, the invention pertains to pyridine- or 1,4-dihydropyridine-based compounds and pharmaceutical compositions comprising these compounds.

L'invention concerne partiellement des méthodes de modulation de la fonction de canaux calciques au moyen de composés à base de pyridine ou de 1,4-dihydropyridine. En outre, l'invention concerne des méthodes de prévention et de traitement d'une maladie cardio-vasculaire ou d'un trouble neurologique dans des organismes comportant un composé identifié par l'invention. En outre, l'invention concerne des composés à base de pyridine ou de 1,4-dihydropyridine et des compositions pharmaceutiques comprenant ces composés.

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