C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 401/12 (2006.01) A61K 31/445 (2006.01) A61K 31/495 (2006.01) C07D 401/14 (2006.01) C07D 417/14 (2006.01)
Patent
CA 2196215
A 1,4-dihydropyridine compound having the formula (I): Image wherein, R1 indicates -COO-A-(3-pyridyl), A indicates a C3-C6 straight chain alkylene group in which one piperazine may be interposed; R2 indicates a C2-C10 alkyl group, alkenyl group or alkynyl group; a lower alkyl group or lower alkenyl group having a substituent; or a cycloalkyl group which may have a substituent; R3 indicates the same group as R1 or -COO-R4; and R4, indicates a lower alkyl group which may have a substituent or its pharmacologically acceptable salt and an anti-allergenic drug, antiphlogistic, drug for overcoming resistance to anti-cancer drugs, or drug for reinforcing the effect of anti-cancer drugs containing the same as effective ingredients.
Composé de 1,4-dihydropyridine de formule générale (I) ou sel pharmaceutiquement acceptable dudit composé, et antagoniste antiallergique, anti-inflammatoire, de résistance antinéoplasique, ou potentialisateur antinéoplasique, contenant tous le même principe actif de formule (I) dans laquelle R<1> représente -COO-A-(3-pyridyle) et A représente alkylène linéaire C3-C6 qui peut posséder un cycle pipérazine interposé; R<2> représente alcényle, alcynyle ou alkyle C2-C10, alkyle inférieur ou alcényle substitué ou éventuellement cycloalkyle substitué; R<3> représente le même groupe que R<1> ou -COO-R<4>; et R<4> représente éventuellement alkyle inférieur substitué.
Fujita Masakazu
Kamakura Mie
Kiue Akira
Miura Teruhisa
Sano Tetsuro
Borden Ladner Gervais Llp
Nikken Chemicals Co. Ltd.
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