C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 211/90 (2006.01) A61K 31/4422 (2006.01) A61K 31/443 (2006.01) A61K 31/4436 (2006.01) A61P 9/04 (2006.01) C07D 405/06 (2006.01) C07D 409/06 (2006.01)
Patent
CA 2544772
The present invention provides certain substituted 1,4-dihydropyridine compounds, including pure enantiomeric forms and pharmaceutical formulations thereof These compounds provide for elevation of .alpha.-MyHC protein levels and .alpha.-MyHC mRNA levels, and most frequently these same compounds provide simultaneous lowering of .beta.-MyHC protein levels and .beta.-MyHC mRNA levels. Thus, these compounds may be used alone or in conjunction with other drugs to treat heart failure.
L'invention concerne des composés 1,4-dihydropyridine substitués particuliers, ainsi que les formes énantiomères pures et des préparations pharmaceutiques de ces composés. Ces composés produisent une élévation des taux de protéines .alpha.-MyHC et des taux d'ARNm de .alpha.-MyHC, et dans la majorité des cas, ces composés produisent simultanément une réduction des taux de protéines .beta.-MyHC et des taux d'ARNm de .beta.MyHC. Ce composés peuvent par conséquent être utilisés seuls ou conjointement à d'autres médicament pour le traitement de l'insuffisance cardiaque.
Melvin Larry
Schreiber Kathy
Bcf Llp
Myogen Inc.
LandOfFree
1,4-dihydropyridine compounds, pharmaceutical compositions,... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with 1,4-dihydropyridine compounds, pharmaceutical compositions,..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and 1,4-dihydropyridine compounds, pharmaceutical compositions,... will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1586891