1,4-dihydropyridine derivatives

Details 1,4-dihydropyridine derivatives 1,4-dihydropyridine derivatives

C - Chemistry, Metallurgy

07

D

C07D 401/12 (2006.01) A61K 31/445 (2006.01) A61K 31/495 (2006.01) A61K 31/505 (2006.01) A61K 31/535 (2006.01) C07D 401/14 (2006.01) C07D 409/14 (2006.01) C07D 471/04 (2006.01) C07D 521/00 (2006.01)

Patent

CA 2320319

1,4-Dihydropyridine derivatives represented by general formula (I) and antagonists against tolerance to anticancer drugs or anticancer drug potentiators containing as the active ingredient these derivatives, pharmacologically acceptable salts thereof or hydrates of the same: wherein R1 represents optionally substituted phenyl or pyridyl; R2 represents lower C1-5 alkyl; R3 represents optionally substituted lower C1-8 alkyl, alkenyl or alkynyl or optionally substituted lower C3-7 cycloalkyl or cycloalkenyl; and R4 represents -A-R5 (wherein A represents C3-5 alkynylene having a triple bond and R5 represents optinally substituted pyridyl, quinolyl, isoquinolyl or pyrimidyl).

L'invention concerne des dérivés de 1,4-dihydropyridine représentés par la formule générale (I), des antagonistes vis-à-vis de la tolérance aux anticancéreux ou aux potentialisateurs d'anticancéreux dont le principe actif renferme les dérivés en question, et les sels pharmaceutiquement acceptables ou les hydrates de ces dérivés. Dans ladite formule, R¿1? est phényle éventuellement substitué ou pyridyle; R¿2? est alkyle inférieur C¿1-5?; R¿3? est alkyle inférieur C¿1-8? éventuellement substitué, alcényle ou alkynyle ou cycloalkyle inférieur C¿3-7? éventuellement substitué ou cycloalcényle; et R¿4? est -A-R¿5? (sachant que A représente alkynylène C¿3-5? à triple liaison et que R¿5? est pyridyle éventuellement substitué, quinolyle, isoquinolyle, ou pyrimidyle).

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