C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
167/208, 260/246
C07D 401/12 (2006.01) C07D 211/90 (2006.01) C07D 401/14 (2006.01) C07D 405/12 (2006.01) C07D 413/14 (2006.01)
Patent
CA 1337764
Disclosed are 1,4-dihydropyridine derivatives of the general formula: Image (wherein X1 and X2 independently represent hydrogen, fluoromethyl, fluoromethoxy, halogen, cyano, or nitro; R1 represents a lower alkyl; R2 represents acyl, alkoxycarbonyl, acylalkyl, an N-alkyl- substituted carbamoylalkyl, alkoxyalkyl, alkoxycarbonylalkyl, acyloxyalkyl, nitratoalkyl, cyanoalkyl, heterocycle-alkyl, haloalkyl, alkenyl, or alkynyl; A represents an alkylene comprising a carbon atom to which 2 alkyls are bonded and having in total at least 5 carbon atoms; m represents the integer 1, 2 or 3 and acid addition salts thereof; a method of production thereof; and pharmaceutical compositions containing such compounds. The compounds have pharmacological activities, in particular potent and long lasting hypotensive activity, coronary vasodilatation, cerebral vasodilatation, peripheral vasodilatation, renal vasodilatation and platelet aggregation inhibitory activity.
561305
Fukata Fumio
Kakeya Nobuharu
Kitao Kazuhiko
Matsui Hiroshi
Mori Takayoshi
Fetherstonhaugh & Co.
Kyoto Pharmaceutical Industries Ltd.
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