C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
260/273, 260/244
C07D 211/82 (2006.01) C07D 471/04 (2006.01)
Patent
CA 1080223
ABSTRACT OF THE DISCLOSURE New 1,4-dihydropyridine derivatives and their process of preparation are provided of the formula:- Image wherein R1 is aryl which may have one or more suitable substit- uent(s) or a heterocyclic group, R2 and R3 are each, same or different, esterified carboxy, and R4 and R5 are each hydrogen; cyano; lower alkyl; or substituted lower alkyl in which the substituent is cyano, hydroxy, acyloxy, hydroxyimino, hydra- zono, lower alkoxyimino, hydroxy(lower)-alkylimino, N'-or N', N'-di-(lower)alkylamino-(lower)alkylimino, hydrazino, hydroxy(lower)-alkylamino, N'-or N', N'- di(lower)alkylamino-(lower)alkylamino, a 5 or 6- membered saturated N-containing heterocyclic-1-yl which may have hydroxy, lower alkyl or hydroxy (lower)alkyl, or oxo wherein thus formed carbonyl may be protected with suitable protecting group; provided that, when one of R4 and R5 is hydrogen or lower alkyl, the other is always cyano or said substituted lower alkyl, and when R4 and R5 are not hydrogen or lower alkyl, both of them are a group selected from cyano and said substituted lower alkyl, or R4 is hydrogen or lower alkyl and R3 and R5 are combined to form a group of the formula: Image , Image , Image or Image wherein R6 is hydrogen or methyl and R7 is 2-(N,N- diethylamino)ethyl or 2-hydroxyethyl; the compounds have vasodilating and anti-hypertensive activity, and are useful for therapeutical treatment in cardio- vascular diseases and hypertension in human beings.
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