1,4-dihydropyridines

Details 1,4-dihydropyridines 1,4-dihydropyridines

C - Chemistry, Metallurgy

07

D

260/294.2, 260/2

C07D 211/90 (2006.01) C07D 401/04 (2006.01)

Patent

CA 1069902

Abstract 1,4-Dihydropyridines characterized by a carbo(aryl- alkoxy) group in the 5-position, an aryl group in the 4- position and a alkanoyl or carbalkoxy group in the 3-position and further optionally substituted in the 1, 2 and 6-positions are prepared through the reaction of an ylidene-.beta.-dicarbonyl compound, which may be generated in situ from the corres- ponding .beta.-dicarbonyl compound and an aldehyde, and an enamino- carboxylic acid ester, which may also be generated in situ from a .beta.-dicarbonyl compound and an amine. The compounds, of which 2,6-dimethyl-3-carbomethoxy-4-(2-nitrophenyl)-5-carbo- benzoxy-1,4-dihydropyridine is a representative embodiment, are coronary dilating, spasmolytic and hypotensive agents.

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