1,4-dihydropyridines

Details 1,4-dihydropyridines 1,4-dihydropyridines

C - Chemistry, Metallurgy

07

D

C07D 471/04 (2006.01) A61K 31/44 (2006.01) A61K 31/495 (2006.01) A61K 31/535 (2006.01) C07D 401/14 (2006.01) C07D 405/14 (2006.01) C07D 409/14 (2006.01) C07D 413/14 (2006.01) C07D 417/14 (2006.01) C07D 487/04 (2006.01) C07D 513/04 (2006.01)

Patent

CA 2045678

2045678 9011280 PCTABScor01 The invention provides compounds of formula (I) and the pharmaceutically acceptable salts thereof, wherein R is an optionally substituted thienyl, benzothienyl, furyl, benzofuranyl, pyridinyl, quinolinyl or isoquinolinyl group; either R1 and R2 are each independently H or C1-C6 alkyl; or R1 and R2, taken together with the nitrogen atom to which they are attached, form a pyrrolidinyl, piperidinyl, morpholinyl, piperazinyl, N'-(C1-C4 alkyl)piperazinyl or N'-(C2-C4 alkanoyl)piperazinyl group; or R1 is H or C1-C4 alkyl and R2 is cyano, C3-C7 cycloalkyl, aryl, heteroaryl or a C1-C4 alkyl group substituted by up to 2 substituents each independently selected from C3-C7 cycloalkyl, C1-C4 alkoxycarbonyl, aryl and heteroaryl; R3 is C1-C6 alkyl or aryl(C1-C4)alkyl; and R4 is either (a) an imidazolyl, triazolyl, pyridinyl, pyridazinyl, pyrimidinyl, pyrazinyl, oxazolyl or thiazolyl group, said group being optionally benzo-, pyrido-, pyridazino-, pyrimido- or pyrazino-fused, or (b) an oxazolo- or thiazolo-fused imidazolyl group, R4 being optionally substituted by up to 3 substituents each independently selected from C1-C4 alkyl, C1-C4 alkoxy, trifluoromethyl, cyano and halo. The compounds are useful for the curative or prophylactic treatment of allergic, hypersecretory and inflammatory conditions in animals, including humans.

Affiliated with

Also associated with

Rating

1,4-dihydropyridines does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with 1,4-dihydropyridines, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and 1,4-dihydropyridines will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1414039