C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
167/202, 167/228
C07D 211/90 (2006.01) A61K 31/44 (2006.01) C07D 401/12 (2006.01)
Patent
CA 1242706
1,4-Dihydropyridines, process for their preparation and their use in medications ABSTRACT A 1,4-dihydropyridine derivative of the formula Image in which R and R1 each independently is hydrogen, C1-C4- alkyl, C1 to C12-alkoxy, C1-C4-halogenoalkoxy, halogen, nitro, trifluoromethyl, Image or Image X is oxygen or sulphur, R4 and R5 each independently is hydrogen, C1-C4- alkyl, C1-C6-alkoxy, halogen, trifluoromethyl, amino or nitro, and R2 and R3 each indepentently is hydrogen, a C1-C10- alkyl, C2-C10-alkenyl or C3-C10-alkinyl radical which is optionally substituted by halogen, hydroxyl, C1-C4-alkoxy, amino, mono- and di-C1-C4-alkylamino, carbo-C1-C6-alkoxy and/or nitro, a C3 to C6-membered - 2 - cycloalkyl radical, a phenyl radical which is optionally substituted by C1-C4-alkyl, C1-C6-alkoxy, halogen, amino and/or nitro, or a phenyl-C1-C3-alkyl radical, or a carbohydrate radical which is option- ally bonded via a C1-C8-alkyl chain to the amide nitrogen atom or a pharmaceutically acceptable acid addition salt thereof which improves the contractility of the heart, raises the blood pressure, lowers the blood sugar, reduces the swelling of mucous membranes and affects the salt and fluid balances of a patient.
455418
Boshagen Horst
Franckowiak Gerhard
Goldmann Siegfried
Gross Rainer
Schramm Matthias
Aktiengesellschaft Bayer
Fetherstonhaugh & Co.
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