C - Chemistry – Metallurgy – 07 – H
Patent
C - Chemistry, Metallurgy
07
H
260/228
C07H 3/00 (2006.01) C07H 13/04 (2006.01) C07H 15/04 (2006.01) C07H 15/06 (2006.01) C07H 15/14 (2006.01) C07H 15/26 (2006.01)
Patent
CA 1229590
ABSTRACT OF THE DISCLOSURE Novel 1,4-dihydropyridines of the formula Image in which R1 and R2 each independently is hydrogen, C1- C4-alkyl, C1 - C12-alkoxy, C1-C4-halogenoalkoxy halogen, nitro, C--C4-halogenoalkyl, C1-C4- halogenoalkylmercapto, Image in which Z is oxygen or sulphur, and R4 and R5 each independently is hydrogen, C1 - C4-alkyl, C1-C6-alkoxy, halogen, C1-C4-halogeno- alkyl, C1-C4-halogenoalkoxy or nitro, or R1 and R2, together with 2 C atoms of the phenyl ring, form the ring Image X is oxygen, sulphur or the radical NR6, R6 is a C1-C6-alkyl group, A is a C2-C10-alkylene group, it being necessary that at least two C atoms are located in the alkylene chain which connects the carbony- loxy group to X, and R3 is a monosaccharide or disaccharide moiety or a protected monosaccharide or disaccharide moiety, or pharmaceutically acceptable addition salts thereof, which exhibit positive inotropic activity and are useful in treating circulatory disorders.
459310
Franckowiak Gerhard
Gross Rainer
Heiker Fred R.
Schramm Matthias
Stoltefuss Jurgen
Aktiengesellschaft Bayer
Fetherstonhaugh & Co.
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