1,4-dihydropyridines with paf-antagonistic activity

Details 1,4-dihydropyridines with paf-antagonistic activity 1,4-dihydropyridines with paf-antagonistic activity

C - Chemistry, Metallurgy

07

D

C07D 211/90 (2006.01) A61K 31/44 (2006.01) A61K 31/535 (2006.01) C07D 405/12 (2006.01) C07D 413/12 (2006.01)

Patent

CA 2074419

ABSTRACT OF THE DISCLOSURE 4-alkyl-1,4-dihydropyridines with activity antagonistic of the PAF-"aceter" of formula (I) are described, in which R is a saturated alkyl chain C1-2; R' is a saturated or unsaturated C1- 16 lineal, branched or cyclic chain that can be interrupted by an oxygen atom and can also represent a 2-(N-morpholine) ethyl group; n is 2 or 3; X is oxygen, sulphur or SO2; Ar represents an aromatic ring that cannot be phenyl when X=S and n=2. The compounds (I) can be prepared (a) by reaction of (II) with (III) and with (IV); or (b) by reacting (V) with (VI) and (IV); or (c) by reaction of (VII) with (VI). In these formulas the different radicals have the meaning given above. Compounds of formula (I) are used for the treatment of pathologic states and disorders in which the PAF-"aceter" participates, being used, for example, in treatment of inflammatory processes, psoriasis, glomerulitis, transplant rejection acute and chronic bronchitis, bronchial asthma, states of shock and allergies Likewise it is used for the treatment of pathologic states and disorders in which it is necessary to stimulate the cellular immunity such as in immunodeficient syndromes and other situations in which the defense capacity is reduced. Image Image (I) (II) H3C-CO-CH2-COO)-(CH2)n-X-Ar R-CHO H3C-CO-CH2-COO-R' (III) (IV) (V) Image Image (VI) (VII)

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