1,4-dioxaspiro¬4,5| decene compounds

Details 1,4-dioxaspiro¬4,5| decene compounds 1,4-dioxaspiro¬4,5| decene compounds

C - Chemistry, Metallurgy

07

D

260/351, 260/277

C07D 317/72 (2006.01) C07D 209/08 (2006.01) C07D 215/227 (2006.01) C07D 277/62 (2006.01) C07D 491/10 (2006.01) C07D 491/113 (2006.01) C07D 493/10 (2006.01) C07D 513/10 (2006.01) C07F 7/10 (2006.01)

Patent

CA 1139760

346987 ABSTRACT OF THE DISCLOSURE Convenient intermediates for preparing 3-substituted-2- hydroxypropyl aryl ether .beta.-blockers, a reaction to the intermediates of the following formula and a conversion to obtain the said .beta.-blockers are disclosed. Image (wherein X is hydrogen or halogen; Y is halogen, hydroxy, lower acyloxy, amino, lower alkylamino, lower aralkylamino, lower acylamino, di-lower alkylamino, lower alkyleneamino, N-lower alkyl-N-lower aralkylamino, di-lower acylamino, N- lower alkyl-N-lower acylamino or N-tri-lower alkylsilylamino; one of P and R combined together with Q shows lower alkylene or alkenylene optionally interrupted by O, N or S and optionally substituted by lower alkyl, lower aralkyl, lower carboxylic acyl, carboxy, protected carboxy; hydroxy, lower alkoxy, lower acyloxy, oxo; amino, lower alkylamino, lower acylamino, nitro, nitroso, lower alkylthio, lower sulfonic acyl or halogen; and remaining R and P is hydrogen or halogen; and dotted line shows the presence of one or two double bonds).

346987

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