1,4-dioxino[2,3-b]pyridine derivatives

Details 1,4-dioxino[2,3-b]pyridine derivatives 1,4-dioxino[2,3-b]pyridine derivatives

C - Chemistry, Metallurgy

07

D

C07D 491/056 (2006.01) A61K 31/435 (2006.01) A61K 31/55 (2006.01) C07D 491/04 (2006.01)

Patent

CA 2090767

Abstract: This invention is concerned with 1,4-dioxino[2,3-b]- pyridine derivatives having formula I Image I wherein each of the groups R is indepenclently selected from hydrogen, hydroxy, lower alkyl, lower alkoxy, CF3, and halogen; R1 is hydrogen or lower alkyl; n is 2, 3, or 4; X is CH2, C=O, or SO2; and Y is substituted or unsubstituted 1,2-phenylene, -(CH2)4-, -CH2CR2R3- or -CH2CR2R3CH2-, in which R2 and R3 are independently hydrogen or lower alkyl, or together 1,4-butanediyl or 1,5-pentanediyl; or pharmaceutically acceptable salts thereof. The compounds according to the invention are strong serotonin ligands with preference for the 5HTlA receptor and may, therefore, find application as anti-depressants or as a drug in combating anxiety disorders.

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