1,4-disubstituted 4-fused phenyl piperidines and piperazines...

Details 1,4-disubstituted 4-fused phenyl piperidines and piperazines... 1,4-disubstituted 4-fused phenyl piperidines and piperazines...

C - Chemistry, Metallurgy

07

D

C07D 405/14 (2006.01) A61K 31/495 (2006.01) C07D 233/36 (2006.01) C07D 307/79 (2006.01) C07D 319/18 (2006.01) C07D 401/14 (2006.01) C07D 403/12 (2006.01) C07D 403/14 (2006.01) C07D 405/04 (2006.01) C07D 405/12 (2006.01) C07D 409/12 (2006.01) C07D 409/14 (2006.01) C07D 411/14 (2006.01) C07D 413/14 (2006.01) C07D 417/12 (2006.01) C07D 417/14 (2006.01)

Patent

CA 2151378

Fused benzo compounds of formula (I), wherein A is a 2 to 6 membered hydrocarbon spacer group, B is a polar divalent group selected from SO, SO2, and a group (a); U is C, N or CH; X is a divalent 3-4 membered chain optionally comprising one or more heteroatoms; R1 is an alipathic hydrocarbon group, arylalkyl or diphenylalkyl; R2 and R3 are hydrogen or alkyl or together form an ethylene or propylene bridge; R4, R5, and R6 are hydrogen or substituents: R7 and R8 are hydrogen or substituents including, a group -COOR9 and a group -CONR10R11: are 5-HT1A receptor ligands useful in the treatment of CNS disorders. Pharmaceutical compositions comprising the compounds and their use for the manufacture of a pharmaceutical preparation are also disclosed.

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