C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 209/48 (2006.01) A61K 31/40 (2006.01) A61P 13/08 (2006.01)
Patent
CA 2430343
The present invention relates to a novel 1,4-disubstituted piperazine derivatives of Formula I, and their pharmaceutically acceptable acid addition salts having excellent uro-selective .alpha.1-adrenoceptor antagonistic activity exceeding those of previously described compounds. The compounds of the present invention hold promise for treating the symptoms of benign prostatic hyperplasia (BPH). The invention also relates to methods for making the novel compounds, pharmaceutical compositions containing the compounds, and method of treating the symptoms of benign prostatic hyperplasia using the compounds.
La présente invention concerne des nouveau dérivés de pipérazine 1,4-disubstitués de formule (I), ainsi que leurs sels d'addition acides pharmaceutiquement acceptables, présentant une excellente activité antagoniste urosélective des récepteurs alpha 1-adrénergiques par comparaison avec celle des composés antérieurs. Les composés de la présente invention permettent de traiter les symptômes associés à l'hyperplasie prostatique bénigne (BPH). L'invention se rapporte également à des procédés de fabrication de ces nouveaux composés, à des compositions pharmaceutiques contenant lesdits composés, ainsi qu'à des méthodes de traitement des symptômes associés à l'hyperplasie prostatique bénigne au moyen des composés précités.
Anand Nitya
Chugh Anita
Gupta Jang Bahadur
Hegde Laxminarayan G.
Jain Sanjay
Deeth Williams Wall Llp
Ranbaxy Laboratories Limited
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