1,4-heterocyclic metalloprotease inhibitors

Details 1,4-heterocyclic metalloprotease inhibitors 1,4-heterocyclic metalloprotease inhibitors

C - Chemistry, Metallurgy

07

D

C07D 241/04 (2006.01) A61K 31/495 (2006.01) A61K 31/535 (2006.01) A61K 31/54 (2006.01) C07D 223/06 (2006.01) C07D 241/08 (2006.01) C07D 265/30 (2006.01) C07D 279/12 (2006.01) C07D 281/00 (2006.01) C07D 281/06 (2006.01) C07D 401/06 (2006.01) C07D 401/12 (2006.01) C07D 405/06 (2006.01) C07D 409/06 (2006.01) C07D 413/06 (2006.01) C07D 417/12 (2006.01)

Patent

CA 2263932

The invention provides compounds of formula (I) as described in the claims, or an optical isomer, diastereomer or enantiomer thereof, or a pharmaceutically- acceptable salt, or biohydrolyzable amide, ester, or imide thereof are useful as inhibitors of metalloproteases. Also disclosed are pharmaceutical compositions and methods of treating diseases, disorders and conditions characterized by metalloprotease activity using these compounds or the pharmaceutical compositions containing them.

L'invention concerne des composés représentés par la formule (I), tel qu'ils sont décrits dans les revendications, ou un de leurs isomères, diastéréomères ou énantiomères optiques, ou un de leurs sels acceptable sur le plan pharmaceutique, de leurs amides, esters ou imides biohydrolysables, utiles en tant qu'inhibiteurs de métalloprotéases. Elle concerne également des compositions pharmaceutiques et des procédés servant à traiter des maladies, des troubles et des états caractérisés par l'activité de métalloprotéases au moyen de ces composés ou des compositions pharmaceutiques les contenant.

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