C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 271/34 (2006.01) A61K 31/27 (2006.01) A61K 31/495 (2006.01) C07D 295/205 (2006.01) C07D 295/215 (2006.01)
Patent
CA 2133744
2133744 9320044 PCTABS00027 Compounds of general formula (II) wherein R3 is C1-35 hydrocarbyl group optionally substituted by one to five substituents, selected from halo, C1-6alkoxy, hydroxy, amino, and mono- or di-C1-4alkyl-amino; and either the dotted line represents a double bond between the 2 and 3 positions of the naphthyl ring; R1 and R4 each represent = O; and R2 represents a group (a) wherein n is 2 or 3, R6 and R7 which may be the same or different, each represent a hydrogen atom, a C1-6alkyl group, optionally substituted by hydroxy, C1-6alkoxy or a group (b) wherein R9 is a C1-6alkyl group optionally substituted by an amino group optionally substituted by one or two alkyl groups, or R6 and R7 may each be a group (c) wherein R8 is a C1-6alkyl group, A is an oxygen atom or a group (d) wherein R5 represents a hydrogen atom, a C1-6alkyl group optionally substituted by hydroxy, C1-6 alkoxy or an amino group optionally substituted by one or two C1-6alkyl groups or R5 is a group (e) wherein R10 is a C1-6alkyl group or R5 is a group (f) wherein p is 2 or 3 and R11 and R12 are as hereinbefore defined for R6 and R7 or, when m is 1 and n is 2 R5 may be linked to R6 so that (g) forms a piperazine ring; or the dotted line represents double bonds between the 1, 2 and 3, 4 positions of the naphthyl ring, and R1, R2 and R4 each represent a group (h) (wherein n, A, R6 and R7 are as hereinbefore defined); and physiologically acceptable salts thereof.
Hudson Alan T.
Yeates Clive L.
Swabey Ogilvy Renault
The Wellcome Foundation Limited
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