1,4 o-linked saccharose derivatives for stabilizing...

A - Human Necessities – 61 – K

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Details

A61K 39/395 (2006.01) A61K 47/26 (2006.01) C07K 1/00 (2006.01)

Patent

CA 2565019

The invention relates to compositions, preferably powdered compositions, for example spray-dried or lyophilized powders that contain an antibody or an antibody derivative and one or more 1,4 O-linked saccharose derivatives selected from the compounds: 1,4 O-linked D-Gal saccharose (lactosucrose), 1,4 O-linked D-Glu saccharose (glucosyl sucrose), or 1,4 O-linked Glu-Glu saccharose (maltosyl sucrose). Preferred combinations contain lactosucrose or a combination of glucosyl and maltosyl sucrose.

L'invention concerne des compositions, de préférence sous forme de poudres telles que, par exemple, des poudres lyophilisées ou séchées par pulvérisation, ces compositions contenant un anticorps ou un dérivé d'anticorps et un ou plusieurs dérivés de saccharose à liaison O en 1,4, sélectionnés parmi les composés suivants: saccharose D-Gal à liaison O en 1,4 (lactosucrose), saccharose D-Glu à liaison O en 1,4 (glucosyle sucrose), saccharose Glu-Glu à liaison O en 1,4 (maltosyle sucrose). Des compositions préférées comportent du lactosucrose ou une combinaison de glucosyle et de maltosyle sucrose.

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