A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/395 (2006.01) A61K 47/26 (2006.01) C07K 1/00 (2006.01)
Patent
CA 2565019
The invention relates to compositions, preferably powdered compositions, for example spray-dried or lyophilized powders that contain an antibody or an antibody derivative and one or more 1,4 O-linked saccharose derivatives selected from the compounds: 1,4 O-linked D-Gal saccharose (lactosucrose), 1,4 O-linked D-Glu saccharose (glucosyl sucrose), or 1,4 O-linked Glu-Glu saccharose (maltosyl sucrose). Preferred combinations contain lactosucrose or a combination of glucosyl and maltosyl sucrose.
L'invention concerne des compositions, de préférence sous forme de poudres telles que, par exemple, des poudres lyophilisées ou séchées par pulvérisation, ces compositions contenant un anticorps ou un dérivé d'anticorps et un ou plusieurs dérivés de saccharose à liaison O en 1,4, sélectionnés parmi les composés suivants: saccharose D-Gal à liaison O en 1,4 (lactosucrose), saccharose D-Glu à liaison O en 1,4 (glucosyle sucrose), saccharose Glu-Glu à liaison O en 1,4 (maltosyle sucrose). Des compositions préférées comportent du lactosucrose ou une combinaison de glucosyle et de maltosyle sucrose.
Bassarab Stefan
Bechtold-Peters Karoline
Friess Wolfgang
Fuhrherr Richard
Garidel Patrick
Boehringer Ingelheim Pharma Gmbh & Co. Kg
Fetherstonhaugh & Co.
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