1,4-substituted cyclic amine derivatives

Details 1,4-substituted cyclic amine derivatives 1,4-substituted cyclic amine derivatives

C - Chemistry, Metallurgy

07

D

C07D 211/22 (2006.01) A61K 31/40 (2006.01) A61K 31/435 (2006.01) A61K 31/445 (2006.01) A61K 31/47 (2006.01) A61K 31/495 (2006.01) A61K 31/535 (2006.01) A61K 31/55 (2006.01) C07D 211/26 (2006.01) C07D 211/74 (2006.01) C07D 217/02 (2006.01) C07D 217/04 (2006.01) C07D 221/04 (2006.01) C07D 295/08 (2006.01) C07D 295/10 (2006.01) C07D 295/12 (2006.01) C07D 295/18 (2006.01) C07D 401/04 (2006.01) C07D 401/14 (2006.01) C07D 403/04 (2006.01) C07D 405/14 (2006.01) C07D 409/14 (2006.01) C07D 417/14 (2006.01) C07D 471/

Patent

CA 2280753

A novel 1,4-substituted cyclic amine derivative represented by the following formula or a pharmacologically acceptable salt thereof: Image (wherein A, B, C, D, T, Y and Z represent each methine or nitrogen; R1, R2, R3, R4 and R5 represent each a substituent; n represents 0 or an integer of 1 to 3; m represents 0 or an integer of 1 to 6; and p represents an integer of 1 to 3.) The compound has a serotonin antagonism and is clinically useful as medicament, in particular, for treating, ameliorating and preventing spastic paralysis or central muscle relaxants for ameliorating myotonia.

Les dérivés amines cycliques 1,4-substitués de la présente invention, qui sont des antagonistes de la sérotonine, conviennent cliniquement comme médicaments permettant de soigner, de soulager ou de prévenir la paralysie spastique, ou comme myotonolytique central soulageant la myotonie. Ces dérivés, ou ceux de leurs sels pharmaceutiquement admis, sont représentés par la formule générale (I). Dans cette formule générale (I), A, B, C, D, T, Y et Z représentent chacun un groupe méthine ou un atome azote, R<1>, R<2>, R<3>, R<4> et R<5> représentent chacun un substituant, n est un entier de 0 à 3, m est un entier de 0 à 6, et p est un entier de 1 à 3.

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