C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 471/04 (2006.01) A61K 31/4164 (2006.01) A61K 31/4184 (2006.01) A61K 31/4439 (2006.01) A61K 31/472 (2006.01) C07D 209/08 (2006.01) C07D 209/16 (2006.01) C07D 213/04 (2006.01) C07D 213/40 (2006.01) C07D 213/75 (2006.01) C07D 215/42 (2006.01) C07D 217/02 (2006.01) C07D 233/54 (2006.01) C07D 235/04 (2006.01) C07D 473/34 (2006.01)
Patent
CA 2400996
The present relates molecules which it is believed provide an alternative with respect to known Rho kinase inhibitors. The Rho kinase regulates axon growth and regeneration, cell motility and metastasis, smooth muscle contraction, and apoptosis. Therefore, Rho kinase is an important target for the many disease applications, including repair in the central nervous system. Thus as mentioned the present relates to an alternate group of compounds that it is believed are able to advantageously inhibit the activity of Rho kinase. It is believed that these compounds may be advantageous exploited over C3 and C3-like fusion proteins because, since they are not peptides or proteins, they will not generate an unwanted immune response; and it is believed that they are readily cell permeable. The present further relates to compounds for promoting repair when applied to the injured mammalian central nervous system, i.e. promote neurite growth..
Lubell William D.
Mckerracher Lisa
Thouin Eryk
Bkp Gp
Lubell William D.
Mckerracher Lisa
Thouin Eryk
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