1,4-substituted cyclohexane derivatives

Details 1,4-substituted cyclohexane derivatives 1,4-substituted cyclohexane derivatives

C - Chemistry, Metallurgy

07

D

C07D 213/81 (2006.01) A61K 31/4164 (2006.01) A61K 31/44 (2006.01) A61K 31/445 (2006.01) A61K 31/47 (2006.01) C07C 237/30 (2006.01) C07D 209/08 (2006.01) C07D 209/16 (2006.01) C07D 209/40 (2006.01) C07D 213/40 (2006.01) C07D 213/56 (2006.01) C07D 213/75 (2006.01) C07D 215/38 (2006.01) C07D 215/42 (2006.01) C07D 217/22 (2006.01) C07D 233/88 (2006.01) C07D 471/00 (2006.01) C07D 471/04 (2006.01) C07D 473/34 (2006.01) C07D 487/04 (2006.01)

Patent

CA 2438909

Allylic compounds represented by the formula (I) are provided, (see formula I) wherein each of R1 to R8, m, n, A and X are as defined in the Specification. These compounds can inhibit Rho kinase, and can find utility in repair of damaged nerves in the central and peripheral nervous system by inducing axon growth and regeneration, and in the treatment by inhibition of Rho kinase in disease states in which Rho kinase is implicated. The compounds are relatively cell permeable and pharmaceutical compositions thereof can promote neurite growth and are also useful for the prevention of cell proliferation in malignant deseases.

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