C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 409/04 (2006.01) A61K 31/415 (2006.01) C07D 231/06 (2006.01) C07D 401/04 (2006.01) C07D 403/04 (2006.01) C07D 405/04 (2006.01)
Patent
CA 2377153
Compounds of formula (I) wherein: X is selected from the group consisting of trihalomethyl, C1-C6 alkyl, and a group of formula (II) wherein: R3 and R4 are independently selected from the group consisting of hydrogen; halogen; hydroxyl; nitro; C1-C6 alkyl; C1-C6 alkoxy; carboxy; C1-C6 trihaloalkyl; and cyano; Z is selected from the group consisting of substituted and unsubstituted aryl; or a pharmaceutically acceptable salt thereof. The compounds are inhibitors of cyclooxygenase-2 activity. They are useful for treating cyclooxygenase-mediated disorders, including, for example, inflamation, neoplastic disorders and angiogenesis-mediated disorders.
L'invention concerne des composés de formule (I) dans laquelle : X est choisi dans le groupe composé de trihalométhyle, alkyle en C¿1?-C¿6?, et un groupe de formule (II) dans laquelle, R¿3? et R¿4? sont choisis indépendamment l'un de l'autre dans le groupe composé d'hydrogène, halogène, hydroxyle; nitro; alkyle en C¿1?-C¿6? ; C¿1?-C¿6? alcoxy ; carboxy; C¿1?-C¿6? trihaloalkyle; et cyano; Z est choisi dans le groupe composé d'aryle substitué et non-substitué; ou d'un sel pharmaceutiquement acceptable de celui-ci. Ces composés sont des inhibiteurs de l'activité cyclo-oxygénase-2. On peut les utiliser pour traiter des troubles induits par la cyclo-oxygénase, y compris, par exemple, les inflammations, les troubles néoplasiques et les troubles induits par l'angiogénèse.
Reddy E. Premkumar
Reddy M. V. Ramana
Mccarthy Tetrault Llp
Temple University - Of The Commonwealth System Of Higher Educati
LandOfFree
1-(4-sulfamylaryl)-3-substituted-5-aryl-2-pyrazolines as... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with 1-(4-sulfamylaryl)-3-substituted-5-aryl-2-pyrazolines as..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and 1-(4-sulfamylaryl)-3-substituted-5-aryl-2-pyrazolines as... will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1557714