1,4-thiazine derivative

Details 1,4-thiazine derivative 1,4-thiazine derivative

C - Chemistry, Metallurgy

07

D

260/243.91

C07D 417/04 (2006.01)

Patent

CA 1226286

NOVEL 1,4-THIAZINE DERIVATIVE ABSTRACT OF THE DISCLOSURE Disclosed is a novel 1,4-thiazine derivative represented by the following general formula I and a pharmaceutically acceptable acid addition salt thereof: Image . . . . . I wherein R1, R2 and R3 respectively represent a hydrogen atom or a lower alkyl group. Also disclosed are processes for preparation of a novel thiazine derivative represented by the general formula I, which comprise reacting a compound of the general formula III with a compound of the general formula A-X' in a compound containing a pyridinyl group as a solvent to obtain a compound of the general formula II: Image Image III II wherein R1, R2 and R3 are as defined above, A represents a group Image in which X represents a halogen atom and n is a number of 1 to 3, and X' represents a halogen atom which may be the same as or different from X, and reacting the compound of the general formula II with sulfur at elevated temperature or stirring the compound of the general formula II in a solution system comprising zinc and a carboxylic acid. Further disclosed is a cardiotonic agent comprising a pharmaceutically acceptable excipient and, as the active component thereof, an effective amount of the novel 1,4-thiazine derivative having the general formula I.

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