1,5 and 3,6- substituted indole compounds having nos...

Details 1,5 and 3,6- substituted indole compounds having nos... 1,5 and 3,6- substituted indole compounds having nos...

C - Chemistry, Metallurgy

07

D

C07D 409/14 (2006.01) A61K 31/4025 (2006.01) A61K 31/439 (2006.01) A61K 31/4436 (2006.01) A61K 31/454 (2006.01) A61K 31/5377 (2006.01) A61K 31/55 (2006.01) C07D 405/14 (2006.01) C07D 409/12 (2006.01) C07D 413/14 (2006.01) C07D 471/08 (2006.01)

Patent

CA 2643822

The present invention features inhibitors of nitric oxide synthase (NOS), particularly those that selectively inhibit neuronal nitric oxide synthase (nNOS) in preference to other NOS isoforms. The NOS inhibitors of the invention, alone or in combination with other pharmaceutically active agents, can be used for treating or preventing conditions such as, for example, stroke, reperfusion injury, neurodegeneration, head trauma, CABG, migraine headache with and without aura, migraine with allodynia, central post-stroke pain (CPSP), neuropathic pain, or chronic pain.

La présente invention concerne des inhibiteurs de l'oxyde nitrique synthétase (NOS), en particulier ceux qui inhibent de façon sélective l'oxyde nitrique synthétase neuronale (nNOS) préférentiellement aux autres isoformes de NOS. Les inhibiteurs de NOS selon l'invention, seuls ou combinés à d'autres principes actifs pharmaceutiques, peuvent être employés dans le traitement prophylactique ou thérapeutique d'états pathologiques tels que, par exemple, les accidents cérébrovasculaires, les lésions de reperfusion, la neurodégénérescence, les traumatismes crâniens, les pontages coronariens, les migraines avec et sans aura, les migraines avec allodynie, les douleurs centrales après accidents cérébrovasculaires, les douleurs névropathiques ou les douleurs chroniques.

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