1,5-benzothiazepine derivatives and processes for preparing...

Details 1,5-benzothiazepine derivatives and processes for preparing... 1,5-benzothiazepine derivatives and processes for preparing...

C - Chemistry, Metallurgy

07

D

260/238.6

C07D 281/10 (2006.01)

Patent

CA 1239399

- 1 - ABSTRACT OF DISCLOSURE The invention provides novel 1,5-benzothiazepine derivatives of the formula: Image (I) wherein R1 is lower alkyl or lower alkoxy, R2 is hydrogen atom or lower alkanoyl, each one of R3 and R4 is lower alkyl, Ring A is a substituted benzene ring of the formula: Image Ra is lower alkyl, lower alkoxy, lower alkylthio or benzyloxy, each one of Rb and Rc is lower alkyl, lower alkoxy or halogen atom, and either one of Rd and Re is fluorine atom and the other one is hydrogen atom, or pharma- ceutically acceptable acid addition salts thereof. These derivatives (I) and their salts are useful as hypotensive agents and/or as cerebral or coronary vasodilators.

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