1,5 benzothiazepines and their use as antihyperlipidemics

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 281/10 (2006.01) A61K 31/554 (2006.01) A61K 31/675 (2006.01) A61K 38/05 (2006.01) A61K 38/06 (2006.01) A61K 45/06 (2006.01) A61P 3/06 (2006.01) C07D 417/12 (2006.01) C07F 9/6536 (2006.01) C07K 5/065 (2006.01) C07K 5/087 (2006.01)

Patent

CA 2431461

The present invention relates to compounds of the formula (I): (wherein variable groups are as defined within) pharmaceutically acceptable salts, solvates, solvates of such salts and prodrugs thereof and their use as ileal bile acid transport (IBAT) inhibitors for the treatment of hyperlipidaemia. Processes for their manufacture and pharmaceutical compositions containing them are also described.

La présente invention se rapporte à des composés représentés par la formule (I), dans laquelle soit R<4> soit R<5> est un groupe représenté par la formule (IA), ainsi qu'à des sels pharmaceutiquement acceptables, des solvates, des solvates de ces sels ainsi que des promédicaments à base de tels sels. L'invention se rapporte également à l'utilisation de ces composés en tant qu'inhibiteurs du transport des acides biliaires iléaux destinés au traitement de l'hyperlipidémie. L'invention se rapporte également à des procédés de fabrication de ces composés ainsi qu'à des compositions pharmaceutiques les contenant.

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