1,5-benzothiazepinone derivatives, their preparations and...

C - Chemistry – Metallurgy – 07 – D

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C07D 281/10 (2006.01) A61K 31/55 (2006.01)

Patent

CA 2081204

2081204 9117153 PCTABS00008 The invention relates to compounds of general formula (I) and pharmaceutically acceptable salts thereof, to processes for the preparation thereof and pharmaceutical compositions containing them. The new compounds, characterized by the presence on the basic nitrogen of at least a branched or cyclic alkyl group and/or by a substitution in the alkyl chain, are endowed with good calcium antagonistic properties and with a longer duration of action in comparison with diltiazem. Said compounds can be usefully utilized in several vascular pathologies such as hypertension and ischemic cardiopathy.

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