C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 281/10 (2006.01) A61K 31/55 (2006.01)
Patent
CA 2081204
2081204 9117153 PCTABS00008 The invention relates to compounds of general formula (I) and pharmaceutically acceptable salts thereof, to processes for the preparation thereof and pharmaceutical compositions containing them. The new compounds, characterized by the presence on the basic nitrogen of at least a branched or cyclic alkyl group and/or by a substitution in the alkyl chain, are endowed with good calcium antagonistic properties and with a longer duration of action in comparison with diltiazem. Said compounds can be usefully utilized in several vascular pathologies such as hypertension and ischemic cardiopathy.
Caliari Saturnino
Fici Francesco
Manghisi Elso
Salimbeni Aldo
Caliari Saturnino
Fici Francesco
Istituto Luso Farmaco D'italia S.p.a.
Kirby Eades Gale Baker
Manghisi Elso
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