1,5-benzothiozepines with cardiovascular activity, methods...

C - Chemistry – Metallurgy – 07 – D

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260/238.6

C07D 281/10 (2006.01) C07D 417/12 (2006.01)

Patent

CA 1223583

ABSTRACT OF THE DISCLOSURE New 1,5-benzothiazepines of the following general formula Image I wherein: R1 represents (C1-4)alkyl, (C1-4)alkoxy or a halo- gen atom; R2 is selected from: benzoyl independently sub- stituted with 1 to 3 (C1-4)alkyl or (C1-4)alkoxy groups, or with halogen atoms; phenylcarbamoyl; phenylcarbamoyl independently substituted with 1 to 3 (C1-4)alkyl or (C1-4) alkoxy groups or with halogen atoms; the groups R5-CO, in which R5 is the radical deriving from a heterocyclic ring optionally substituted by a (C1-4)alkyl or a (C1-4)alkoxy radical, or by a halogen atom; R3 and R4 independently re- present (C1-4)alkyl groups; and salts therewith of pharama- ceutically acceptable acids. The compounds of the inven- tion possess cardiovascular utility.

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