1,5-benzoxathiepin derivatives, their production and use

Details 1,5-benzoxathiepin derivatives, their production and use 1,5-benzoxathiepin derivatives, their production and use

C - Chemistry, Metallurgy

07

D

167/223, 260/266

C07D 411/06 (2006.01) A61K 31/495 (2006.01) C07D 327/02 (2006.01)

Patent

CA 1271754

24205-694 ABSTRACT OF THE DISCLOSURE Compounds of the formula: Image wherein R is hydroxy or lower alkoxy and X is lower alkoxycarbonyl, and their salts possess serotonin S2 receptor blocking activity, calcium antagonism, actions to relieve cerebral vasospasm and to improve renal circulation, and diuretic and antithrombotic activities, and are useful as prophylactic and therapeutic agents for ischemic cardiopathies, thrombosis, hypertension and cerebral circulatory disorders.

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