1,5-benzoxathiepin derivatives, their production and use

Details 1,5-benzoxathiepin derivatives, their production and use 1,5-benzoxathiepin derivatives, their production and use

C - Chemistry, Metallurgy

07

D

260/327.7

C07D 327/02 (2006.01) C07D 411/02 (2006.01) C07D 411/06 (2006.01) C07D 411/12 (2006.01)

Patent

CA 1258463

Abstract of The Disclosure Novel 1,5-benzoxathiepin derivatives of the formula: Image (IV) [wherein R1 and R2 are independently hydrogen, halogen, hydroxy, lower alkyl or lower alkoxy; X is hydrogen, optionally substituted lower al? ally substituted aryl or a carboxyl group which may be esterified or amidated; Y is Image or Image (wherein R5 is hydrogen, acyl or optionally substituted carbamoyl); m is an integer of 0 to 2; n is an integer of 1 to 6; and W' is halogen or sulfonyloxy] and salts thereof are useful as intermediates for producing related compound which exhibit serotonin S2 receptor blocking activity, calcium antagonism, actions to relieve cerebral vasospasm and to improve renal circulation and diuretic and antithrombotic activities.

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