1,5-bis-(1,4-benzodioxin-2-yl)-3-azapentane-1,5-diols,...

Details 1,5-bis-(1,4-benzodioxin-2-yl)-3-azapentane-1,5-diols,... 1,5-bis-(1,4-benzodioxin-2-yl)-3-azapentane-1,5-diols,...

C - Chemistry, Metallurgy

07

D

260/354.5

C07D 319/20 (2006.01)

Patent

CA 1169079

4-13095/CGC 927/+ 1,5-Bis-(1,4-benzodioxin-2-yl)-3-azapentane-1,5-diols, process for their manufacture, pharmaceutical preparations containing these compounds and their therapeutic application. Abstract of the disclosure The invention concerns the novel, specific stereoisomer 1-(2,3- dihydro-1,4-benzodioxin-2S-yl)-5-(2,3-dihydro-1,4-benzodioxin- 2R-yl)-3-azapentane-1R,5S-diol and acid addition salts thereof, which have antihypertensive and moderate bradycardic activity. They are prepared for example by hydrogenolysis of the benzyl group from 3-benzyl-1-(2,3-dihydro-1,4-benzodioxin-2S-yl)-5-(2,3-dihydro-1,4 benzodioxin-2R-yl)-3-azapentane-1R,5S-diol.

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