1,5-diphenyl-3-pyridinylmethylamino-1,5-dihydropyrrolidin-2-...

Details 1,5-diphenyl-3-pyridinylmethylamino-1,5-dihydropyrrolidin-2-... 1,5-diphenyl-3-pyridinylmethylamino-1,5-dihydropyrrolidin-2-...

C - Chemistry, Metallurgy

07

D

C07D 401/12 (2006.01) A61K 31/4025 (2006.01) A61P 25/00 (2006.01) C07D 207/38 (2006.01)

Patent

CA 2667210

Compound and pharmaceutical compositions of Forumla by blockade of the CB1 receptors via an inverse agonism mechanism, and are useful for reducing body weight in mammals, cognitive impairment associated with schizophrenia, mitigating treatment emergent weight gain observed during treatment with antipsychotics and have increased bioavailabilty.

L'invention concerne des composés et des compositions pharmaceutiques de formule par blocage des récepteurs CB1 via un mécanisme d'agonisme inverse qui sont utiles pour réduire la masse corporelle chez les mammifères, le trouble cognitif associé à la schizophrénie, atténuer la prise de poids liée au traitement observée pendant un traitement avec des antipsychotiques et ont une biodisponibilité accrue.

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