C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 231/12 (2006.01) A61K 31/415 (2006.01)
Patent
CA 2177824
A class of 1,5-diphenyl pyrazoles is described for the treatment of inflammation, including treatment of pain and disorders such as arthritis. Compounds of particular interest are of formula (I), wherein R1 is methylsulfonyl; wherein R2 is selected from -CF3, -CF2Cl, -CF2H, -CF2CF3 and - CF2CF2CF3; and wherein R3 is fluoro or chloro; or a pharmaceutically- acceptable salt thereof.
La présente invention concerne une classe de 1,5-diphényl pyrazoles utilisables pour le traitement des inflammations, y compris le traitement des douleurs et troubles tels que l'arthrite. Les composés présentant un intérêt tout particulier sont conformes à la formule générale (I) où R?1¿ est méthylsulfonyl; où R?2¿ est sélectionné dans le groupe -CF¿3?, -CF¿2?Cl, -CF¿2?H, -CF¿2?CF¿3? et -CF¿2?CF¿2?CF¿3?; et où R?3¿ est fluoro ou chloro ou un de ses sels compatibles sur le plan pharmaceutique.
Bertenshaw Stephen R.
Lee Len F.
G.d. Searle & Co.
Osler Hoskin & Harcourt Llp
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