C - Chemistry – Metallurgy – 07 – F
Patent
C - Chemistry, Metallurgy
07
F
C07F 9/38 (2006.01) A61K 31/4166 (2006.01) A61K 31/4178 (2006.01) A61K 31/675 (2006.01) A61P 19/10 (2006.01) A61P 27/06 (2006.01) C07D 233/32 (2006.01) C07D 403/06 (2006.01) C07D 403/12 (2006.01)
Patent
CA 2487977
This invention relates to potent selective agonists of the EP4 subtype of prostaglandin E2 receptors of formula (I), their use or a formulation thereof in the treatment of glaucoma and other conditions which are related to elevated intraocular pressure in the eye of the patient. This invention further relates to the use of the compounds of this invention for mediating the bone modeling and remodeling processes of the osteoblasts and osteoclasts.
L'invention concerne des agonistes sélectifs efficaces du sous-type EP¿4? des récepteurs de prostaglandine E2 de formule (I), leur utilisation ou une formulation les incluant pour le traitement du glaucome et d'autres troubles liés à une pression intraoculaire élevée chez un patient. La présente invention porte également sur l'utilisation des composés de l'invention pour induire les processus de modelage et de remodelage osseux des ostéoblastes et des ostéoclastes.
Billot Xavier
Young Robert N.
Merck Frosst Canada & Co./merck Frosst Canada & Cie
Merck Frosst Canada Ltd.
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
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